$60M PROGRAM jointly funded with Temasek Trust
Reducing frailty progression by 25% has the potential to prevent 71,000 hospitalizations and 8,000 deaths annually from falls alone in the US, and to benefit 87 million older adults across the world.
But poor health as we age is not inevitable. The rising number of centenarians and supercentenarians shows that it is possible for humans to live well for a very long time. Such exceptional individuals are remarkably resilient: they enjoy good health for most of their lives and are able to ‘bounce back’ after significant stress events such as falls, infection, surgery, or major psychosocial stresses. Resilience gives us a new way to understand health spans, highlighting the need to restore steady-state and dynamic resilience to prevent frailty and age-related multimorbidity
“Dynamic Resilience is aimed at extending health spans – the duration of life that is spent in good health – so that more people can live fuller and healthier lives for longer.”
The Dynamic Resilience program has three ambitious and interlinked goals: (1) novel multimodal biomarker signatures of resilience predictive of health outcomes following a stress event using biobanked longitudinal human cohorts; (2) underpinning mechanisms of frailty and resilience using human-centric in vitro and /or in silico stress-testable models at multiple scales (cells, tissue and organism); and (3) proof-of-concept experimental studies and clinical trials of preventative interventions to improve biological resilience in at-risk people prior to predictable stress events (e.g. surgery), targeting reduction in progression to further frailty or death by at least 25% in intervention versus control groups.
“We all share a desire to be healthy and live independently to our last breath. To do so, we will need to be able to measure, support, and maintain robust levels of dynamic resilience."
– Regina E. Dugan, Wellcome Leap CEO