Home » news

news

Wellcome Leap Announces $2 Million Prize in $50 Million Quantum for Bio Challenge Program

First-ever demonstration of an end-to-end quantum-classical workflow for simulating complex therapeutics, unlocking a credible path to near-term quantum advantage in health.

April 16, 2026

Share this work

San Diego, CA – April 16, 2026 – Wellcome Leap (Leap), a U.S. nonprofit founded by the Wellcome Trust to accelerate breakthroughs in human health, today announced the outcome of its Quantum for Bio (Q4Bio) Supported Challenge Program. The $50 million initiative was designed to support the development of new algorithms (with $40 million in research funding) and test them through a rigorous, competitive challenge to determine whether quantum computing could deliver provable advantage for critical, classically intractable challenges in biology and healthcare. Up to $10 million in potential prizes was available.

Launched in 2023, Q4Bio set out to answer a fundamental question: What if we could develop new algorithms that deliver quantum advantage for health? At the time, the field was marked by significant promise, but limited evidence of practical application. Over the course of 30 months, the program brought together experts across quantum software, hardware, and biology as collaborative teams to identify high-impact biological use cases and co-develop the quantum solutions required to solve them. Finalist teams were led by Infleqtion, University of Nottingham, Harvard University, Stanford University, Algorithmiq, and the University of Oxford.

Two prize categories were defined: A $5 million grand prize for demonstrating quantum advantage over best-in-class classical baselines and a $2 million prize for each team that successfully demonstrated an experimental realization of their application on a quantum computer with more than 50 qubits, a program depth of O(10³–10⁴), and a clear trajectory to scale toward quantum advantage.

Today, Wellcome Leap has announced that Algorithmiq has successfully met the criteria for the $2 million prize.

The multidisciplinary team led by quantum software company Algorithmiq, with quantum computing support from IBM, and biological expertise from Cleveland Clinic, successfully demonstrated an experimental realization of their solution – identifying a scalable path to future quantum advantage. The team developed an end-to-end quantum-classical workflow to calculate excited-state properties of a photosensitizer drug relevant for photodynamic cancer therapy.

Importantly, the true impact of Q4Bio extends beyond the prize itself. Through rigorous testing of current capabilities, teams across the program delivered critical scientific contributions that establish a clear, evidence-based understanding of how quantum computing can be applied in human health.

“When we started the Wellcome Leap program, it wasn’t clear exactly how or where quantum computing could meaningfully impact biology,” said Shihan Sajeed, Program Director for Q4Bio. “Q4Bio was designed to create new solutions that would answer that question within real biological and hardware constraints. What we now have is a much clearer understanding of where quantum can create value, where it cannot, and what needs to happen next.”

What Q4Bio established

Rather than focusing on theoretical exploration, Q4Bio tested quantum approaches against real-world biological problems within the physical limits of current hardware.

Across the program, teams validated biological use cases where quantum hardware may offer advantage, advanced the performance of classical approaches, and developed end-to-end hybrid quantum–classical pipelines connecting biological questions to computational solutions.

Together, this work provides a rigorous assessment of what is computationally feasible today – and what depends on future hardware advances. It represents one of the most coordinated efforts to date to apply quantum computing to address critical health challenges.

Looking ahead

While today’s quantum systems remain limited for most applications, Q4Bio provides a roadmap for how quantum capabilities can evolve alongside hardware improvements. The pipelines and workflows developed through the program are expected to adapt as more advanced, fault-tolerant quantum systems emerge, enabling increasingly complex biological applications over time.

Building on the progress of Q4Bio, Wellcome Leap expects to launch a follow-on initiative to further advance quantum-enabled approaches to biology and health applications. The team is currently evaluating next steps and welcomes discussions with partners interested in supporting future programs.

About Wellcome Leap

Wellcome Leap is a billion-dollar breakthrough engine for human health – at global scale. Founded by the Wellcome Trust in 2020 as a U.S. nonprofit, Wellcome Leap builds and executes bold, unconventional programs with the urgency required to deliver breakthroughs in years, not decades. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone. For more information, read how Wellcome Leap is Changing the Business of Breakthroughs and visit www.wellcomeleap.org. To learn more about the Q4Bio program, visit www.wellcomeleap.org/q4bio or the program’s LinkedIn page.

Share this work

Suzanne Nora Johnson

Suzanne Nora Johnson Joins Wellcome Leap Board of Directors

March 3, 2026

Share this work

San Diego, CA – March 3, 2026 – Wellcome Leap (Leap), a U.S. nonprofit founded by the Wellcome Trust to accelerate breakthroughs in human health, today announced that Suzanne Nora Johnson has joined its Board of Directors.

“Innovation in healthcare has too often moved at a snail’s pace,” said Suzanne Nora Johnson. “What inspires me about Wellcome Leap is its deliberate departure from that model – setting bold, time-bound goals, assembling global multidisciplinary teams, and holding programs accountable to measurable milestones. This combination of urgency, agility, and collaboration defines a new model of philanthropic investment – one built to accelerate breakthroughs in years, not decades. It is precisely the kind of approach healthcare innovation needs.”

Suzanne brings to Leap more than two decades of leadership at the intersection of global finance, healthcare, and institutional strategy. As former Vice Chairman of The Goldman Sachs Group, Inc., she helped guide the firm through periods of transformation, serving on its Management Committee and chairing the Global Investment Research Division. She also headed Goldman Sachs’ Global Healthcare Business and founded the firm’s Latin American business – roles that required navigating complex markets, scaling ideas globally, and identifying opportunities to drive impact.

As a current member of the Pfizer Inc. Board of Directors and former Chair of the Intuit Inc. Board of Directors, Suzanne has developed deep insight into how innovation moves from research to real-world application. Across the public and private sectors, her experience has involved aligning resources, talent, and institutional leadership to drive meaningful, measurable outcomes – expertise that will contribute to Leap’s focus on advancing bold, unconventional programs.

“Suzanne shares our belief that we can increase the number of breakthroughs in human health if we challenge ourselves to work with greater speed and across disciplines, organizations, and countries,” said Jay Flatley, Chairman of the Board. “She brings deep experience from both finance and healthcare, but just as importantly, she brings decades of demonstrated commitment to driving progress in human health.”

In addition to her corporate leadership, Suzanne serves on the boards of several nonprofit and academic institutions, including the Brookings Institution (Co-Chair), the Markle Foundation (Chair), and the University of Southern California (Chair). She is a member of the American Academy of Arts and Sciences, the Council on Foreign Relations, and the Foreign Policy Association, and has contributed to Global Agenda Councils of the World Economic Forum. She is also a Henry Crown Fellow of the Aspen Institute.

Suzanne received her J.D. from Harvard Law School and her B.A. from the University of Southern California.

About Wellcome Leap

Wellcome Leap is a billion-dollar breakthrough engine for human health – at global scale. Founded by the Wellcome Trust in 2020 as a U.S. nonprofit, Wellcome Leap builds and executes bold, unconventional programs with the urgency required to deliver breakthroughs in years, not decades. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone. For more information, read how Wellcome Leap is Changing the Business of Breakthroughs and visit www.wellcomeleap.org.

Share this work

emerging breakthroughs

A showcase of our global programs.

JANUARY 13-14, 2026 / San Francisco, CA

Wellcome Leap featured scientific innovations from 10 teams across 5 programs spanning neurodevelopment, maternal care, depression, surgical training, and RNA manufacturing.

TO LEARN MORE, CONTACT transitions@wellcomeleap.org

LEAP PROGRAMS AT THE EVENT / 1kD / IN UTERO / MCPSYCH / SAVE / R3G

Program Challenge: What if we’ve been approaching the first 3 years of a child’s development all wrong?

Baylor

Advancing a first-in-class product that supports healthy infant neurodevelopment by restoring key early-life gut microbiome functions in the first months of life.

SHOWCASE VIDEO

Program Challenge: What if we could reduce the number of stillborn babies by half by detecting emerging complications in utero?

Maternitec

Building the world’s first wearable fetal activity tracker, providing reassurance now, and an early warning sign of fetal distress in the future.

SHOWCASE VIDEO
Maternitec

Medicines360

Transforming data-driven, personalized insights at every stage of pregnancy, powered by comprehensive risk stratification, to help identify the conditions responsible for 50% of stillbirths.

SHOWCASE VIDEO

SADIE

Transforming how ultrasound can be used to guide clinical decisions around the timing of birth by providing critical information on fetal oxygenation.

SHOWCASE VIDEO
Sadie

Program Challenge: What if we could double the number of people who receive an effective treatment for depression? On the first try.

Eiro

Building an AI-powered Precision Health Platform that integrates complex biomarker data to predict the most effective depression treatment for each individual – shortening and personalizing their treatment journey.

SHOWCASE VIDEO

Program Challenge: What if we could shorten and improve training and not all surgical providers needed to be MDs?

Grendel

Introducing an AI-powered, gamified, immersive simulation training platform for minimally invasive surgery skills, coupled with quantifiable performance metrics to enable trainees to achieve competence faster.

Grendel

Chipsense

Developing a point of care solution with biosensors that can accurately measure multiple reproductive hormones in a single test device, for routine monitoring at home to inform hormone therapy and care.

SHOWCASE VIDEO
Chipsense

Keysuite

Democratizing access to gasless laparoscopic surgical equipment and techniques through a low-cost, highly functional and portable laparoscopic kit, manufactured and serviced locally, and scalable regionally.

SHOWCASE VIDEO

StatOS

Developing a real-time bedside test to measure oxidative stress in patients for early detection of deterioration and recovery.

SHOWCASE VIDEO
StatOS
Program Challenge: What if a distributed network of biofoundries could produce mRNA biologics for cancer, Zika, or RA, and also surge capacity in the advent of a pandemic?

RiboPro

Transforming how RNA medicines are developed and manufactured with RiboFlux: the world’s first integrated, continuous‑flow mRNA manufacturing system designed to move seamlessly from research to GMP‑scale production.

Ribopro

Centillion

Advancing Biofoundry-in-a-Box™ (BiaB™): a fully automated, end-to-end RNA manufacturing platform built on a patented continuous-flow control strategy, delivering programmable, GMP-quality RNA from research through early development.

A picture of medical equipment.

See the full Emerging Breakthroughs video

TO LEARN MORE, CONTACT transitions@wellcomeleap.org

Stay up to date on our programs.

Wellcome Leap and Medicines360 logos

Wellcome Leap and Medicines360 Announce Partnership to Accelerate Development and Access to New Lifesaving Pregnancy and Stillbirth Risk-Reduction Tools for Women Worldwide

Collaboration will transform biomarkers into precision insights across gestation – so every pregnancy has the best chance of a healthy outcome.

Jan 12, 2026

Share this work

SAN FRANCISCO, Jan. 12, 2026 – Wellcome Leap, a U.S. non-profit accelerating breakthroughs in human health, and Medicines360, a women’s health innovation organization, today announced a collaboration to accelerate breakthrough advances in maternal health technologies designed to improve outcomes for mothers and babies around the world. The partnership includes new blood biomarker-based tests and non-invasive retinal imaging technologies that are designed to accurately predict risk for common pregnancy complications associated with roughly half of all stillbirths.

Globally, more than two million pregnancies end in stillbirth every year.1 In the U.S., more than one in 150 births end in stillbirth – a burden disproportionately affecting families in low-income areas.2

“Before you finish this paragraph, another baby will be stillborn. Every 16 seconds, a mother, a family, grieves this loss. Women deserve clearer insights of their pregnancy health,” said Regina E. Dugan, CEO of Wellcome Leap. “By combining Wellcome Leap’s scientific breakthroughs with Medicines360’s global innovation and access model, we can deliver predictive tools to mothers around the world – before complications arise. Before it’s too late.”

This partnership will accelerate the scientific advances discovered in Wellcome Leap’s In Utero program – a $50 million initiative launched in 2022 to create scalable methods to measure, model, and predict gestational development in utero. The technologies developed during the program are critical for early stillbirth risk detection and include:

  • The University of Cambridge’s discovery of new blood-based biomarkers of fetal growth restriction, gestational diabetes mellitus, and preeclampsia.
  • The University of Edinburgh’s advances in retinal eye imaging technology, which is intended to detect vascular-related conditions like preeclampsia.

With Medicines360’s focus on building access into every phase of the innovation process, this partnership will seek to speed translation of these scientific discoveries into life-saving technologies and ensure broad, equitable availability for women globally. This is especially critical for women in rural and under-resourced communities, who face the greatest barriers to timely maternal care. Typically, the development process takes decades – this partnership aims to achieve commercialization in years so women can have the care they deserve as soon as possible.

“This initiative is designed to reshape the future of maternal care,” said Dr. Andrea Olariu, CEO of Medicines360. “Every pregnancy deserves precise, individualized risk assessment to inform life-saving interventions. Partnering with Wellcome Leap allows us to translate groundbreaking science into commercial products for use in clinical practice, and at a record pace. Together, we can change the trajectory of pregnancy outcomes for women worldwide, while prioritizing access from day one.”

An October 2025 JAMA study3, one of the most comprehensive analyses of stillbirth burden in the U.S. to date, found that 30% of stillbirths occur in pregnancies with no currently identifiable risk factors. To meet this urgent need, Wellcome Leap and Medicines360 are seeking additional funders to scale these critical technologies to mothers everywhere.

About Wellcome Leap

Wellcome Leap is a billion-dollar breakthrough engine for human health – at global scale. Founded by the Wellcome Trust in 2020 as a U.S. nonprofit, Wellcome Leap builds and executes bold, unconventional programs with the urgency required to deliver breakthroughs in years, not decades. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone. For more information, read how Wellcome Leap is Changing the Business of Breakthroughs and visit www.wellcomeleap.org.

About Medicines360

Medicines360 is a women’s health innovation organization with a mission to be a catalyst for change, fearless in the pursuit of creative approaches to solving consequential women’s health issues. Medicines360 transforms novel ideas into life-changing products that improve the lives of all women, with a focus on ensuring access from day one. For more information about Medicines360 and the 360 Innovation Hub™, visit: www.medicines360.org. The technologies described are under development and have not been approved or cleared by the U.S. Food and Drug Administration or other regulatory authorities.
  1. https://www.who.int/health-topics/stillbirth#tab=tab_1 accessed Sept. 15, 2025
  2. https://hsph.harvard.edu/news/stillbirths-in-the-u-s-higher-than-previously-reported-often-occur-with-no-clinical-risk-factors/
  3. Sullivan HK, Sinaiko AD, Fox K, Armstrong JC, Clapp MA, Cohen JL. Stillbirths in the United States. JAMA. 2025;334(22):2033–2035. doi:10.1001/jama.2025.17392

Share this work

leap + pivotal

Wellcome Leap and Pivotal Commit $100 Million to Women’s Health Research to Deliver Breakthroughs in Years, Not Decades

Wellcome Leap and Pivotal Commit $100 Million to Women’s Health Research to Deliver Breakthroughs in Years, Not Decades

Partnership brings Leap’s total investment to a quarter billion dollars – advancing toward a $1 billion goal to transform outcomes for women worldwide.

September 10, 2025

Share this work

San Diego, CA – September 10, 2025 – Wellcome Leap, a U.S. non-profit, and Pivotal, a group of organizations founded by Melinda French Gates, today announced a $100 million partnership to accelerate women’s health research. The joint effort will focus on delivering breakthroughs in women’s health research in areas with some of the highest burdens of morbidity and mortality, such as cardiovascular health, autoimmune disease, and mental health.

Women experience health issues differently, disproportionately, and uniquely – yet funding remains inadequate. Despite living longer, women spend an average of nine years of their lives in poor health, which is 25 percent more compared to men1. Additionally, only 1 percent of global health research funding was allocated to women’s health conditions beyond cancer in 20201.

This new funding partnership will support the launch of two new women’s health programs kicking off in 2026, using Leap’s proven model for delivering breakthroughs. This also pushes Leap’s total investment in women’s health to $250 million, putting the organization one step closer to a bold goal of $1 billion in philanthropic capital dedicated to accelerating breakthroughs for under-researched, under-prioritized, and underfunded conditions that disproportionately impact women at every stage of life.

“Women’s health is chronically underfunded, chronically under-researched, and, as a result, not well understood. We need to look at this broken status quo through new eyes and stop tolerating women’s pain and suffering,” said Melinda French Gates, Philanthropist and Founder of Pivotal. “With Wellcome Leap’s proven model, we expect to see outcomes years – even decades – sooner than we would through other approaches. This is a unique chance for funders and partners to step up and be part of something truly revolutionary. Progress is ours if we’re willing to reach for it, and the results will touch the lives of women all over the world.”

With the support of Wellcome Trust and the leadership of CEO Regina E. Dugan, former Director of DARPA, the U.S. Defense Advanced Research Projects Agency, and the first woman to lead the agency, Leap built the first-ever application of DARPA’s model for human health on a global scale.

“We need more breakthroughs, and we need them faster,” said Dugan. “I have seen how ambitious, emotionally invested teams with clear goals can overcome obstacles, collapse timelines, and deliver solutions once thought impossible. Together with Melinda and the team at Pivotal, we share a determination to change the future for women. Because breakthroughs in women’s health are not a matter of chance – they are a matter of choice. And it’s time. Women have waited long enough.”

The Wellcome Leap Breakthrough Model Delivers Results in Years, Not Decades

Leap represents a new model for research – designed to be fast, agile, and networked across disciplines, organizations, and countries. Its expert-designed, milestone-driven, three-year programs are built to tackle urgent health challenges. This proven approach to generating breakthroughs is modeled on DARPA, which has arguably the longest standing track record of radical breakthroughs in human history – including the internet, miniaturized GPS, lasers, and stealth technology. In five years, Wellcome Leap has launched 12 programs spanning 30 countries, powered by a growing network of more than 160 institutions, nonprofits, and companies – representing millions of researchers across six continents.

To date, Leap has invested $150 million in three programs designed to improve health outcomes at every stage of a woman’s life, including advances in:

  • Maternal care focused on cutting the rate of stillbirths in half
  • Reducing a woman’s lifetime risk of Alzheimer’s by 50 percent
  • Shrinking the average time to diagnose and treat heavy menstrual bleeding from five years to five months

Leap’s approach is already translating into tangible progress. In the stillbirth prevention program, global research teams were mobilized in under 100 days. Among the emerging results is evidence that a maternal blood test could predict conditions that can lead to stillbirth – including fetal growth restriction, gestational diabetes, and pre-eclampsia – with greater than 80 percent accuracy, as early as 12 weeks. This early insight could equip clinicians and community health workers with powerful new tools to prevent stillbirth.

Closing the women’s health gap is both a moral and an economic imperative, with the potential to add more than $1 trillion to the global economy annually by 20401. Real impact will require a global coalition of funders willing to commit resources at the scale the challenge demands.

Philanthropic leaders and organizations committed to bold, transformative change will be essential to advancing women’s health worldwide. To explore a leadership partnership, contact womenshealthresearch@wellcomeleap.org.

Watch the announcement live on LinkedIn here beginning at 9:30 AM EST.

About Wellcome Leap

Wellcome Leap is a billion-dollar breakthrough engine for human health – at global scale. Founded by the Wellcome Trust in 2020 as a U.S. nonprofit, Wellcome Leap builds and executes bold, unconventional programs with the urgency required to deliver breakthroughs in years, not decades. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone. For more information, read how Wellcome Leap is Changing the Business of Breakthroughs and visit www.wellcomeleap.org.

About Pivotal

Founded by Melinda French Gates in 2015, Pivotal is a group of organizations that work to accelerate the pace of social progress and expand women’s power and influence in the U.S. and around the world. Through high-impact investments, philanthropy, partnerships, and advocacy, Pivotal seeks to remove the barriers that hold women—and all people—back. Pivotal includes Pivotal Ventures, LLC and Pivotal Philanthropies Foundation, a 501(c)(3) private foundation launched in 2022. Learn more at https://www.pivotalventures.org/.

Share this work