news

Kidney Tissue

Wellcome Leap announces over $300M in additional funding.
Now more than Half a Billion Dollars for catalyzing breakthroughs in human health.

February 2, 2022

Share this work

Share on facebook
Share on twitter
Share on linkedin
Image shows kidney tissue constructed from organoid building blocks by Jennifer Lewis (Harvard) and Ryuji Morizane (MGH) labs. The ultimate goal is to create tissues that can restore sufficient function to free patients from dialysis.
Los Angeles – Feb. 2, 2022: Wellcome Leap (Leap), a U.S. based non-profit organization founded by the Wellcome Trust to accelerate breakthroughs for global health, has today announced an additional $335M in new funding. Combined with the $300M allocated at launch, the organization will have well over half a billion dollars at work.

The COVID-19 pandemic brought human health and the threat of disease into a focus not seen in modern history. In one of the greatest scientific accomplishments of our generation, mRNA technology has demonstrated the ability to change the timeline for developing and delivering a new vaccine from years to months. And the entire world was witness to that demonstration.

“The last 2 years have laid bare how much work we have to do in health, equity, and care for the planet. They have also revealed the difference a breakthrough makes,” said CEO, Dr. Regina E. Dugan. “We need more breakthroughs to solve the urgent challenges facing the world. And we need them faster.”

The Wellcome Trust recently announced its biggest funding commitment to science and health in its 85-year history. It plans to raise charitable spending to £16 billion (over $21.5 billion) over the next decade to fund science that supports a healthy future for everyone. It has also committed an extra £750 million (over $1 billion) to fund large-scale, high-impact activities across five years, which they anticipate will grow to £1 billion next year.

Dr. Jeremy Farrar, Director of Wellcome said: “Support for long-term, basic science is vital. We founded Wellcome Leap because we also need to ensure that somewhere in the system there is a truly disruptive element that can take bigger risks, challenge the consensus point of view, and work globally to find the best talent and ideas to push forward. We expect to allocate about 5% of our funding into the future to Wellcome Leap as a complement to our other investments. Since its inception, Wellcome Leap has hit the ground running with ambitious programs that seek to deliver transformative results from mRNA production to mental health and physiology. Bold initiatives like these are key to maintaining the momentum of the last two years. We couldn’t be more delighted, or impressed, with the work to date.”

Jay Flatley, Chair of Wellcome Leap, said “What Wellcome Leap has achieved in less than two years has exceeded all our expectations and is on par with the best execution I’ve seen in any commercial setting. The assembly of this unicorn leadership team is one of Wellcome Leap’s most important accomplishments – they are inspiring, outcome focused, and uniquely qualified to take on the challenge.”

All Wellcome Leap programs aim to deliver breakthroughs in human health over 5 – 10 years and demonstrate seemingly impossible results on seemingly impossible timelines. To do so, programs have ambitious goals that are also testable and measurable – the setting of the bar for a program is among the hardest things we do. It requires Program Directors who are scientifically accomplished and who dare to ask ‘what if?’ They formulate the program and serve as conductors of a global, dynamic network of performers working together to solve problems they cannot solve alone.

But an ambitious goal is not enough. We have to change the boundary conditions of the work itself. Wellcome Leap is optimized for breakthroughs – this requires speed, agility, and changes across all dimensions of operation, selection, and execution to systematically increase the probability of success.

Wellcome Leap has funded 5 programs that aim to create 10X improvements in three dimensions: increase understanding of human health and disease, transform economics, and increase the speed, scale and equity of access. All programs are focused on achieving tangible gains that demonstrate at convincing scale the ability to overcome some of the most challenging threats to human health from depression, brain development, and infectious diseases to the platforms needed to transform drug development, production, and access.

About Wellcome Leap Wellcome Leap builds and executes bold, unconventional programs, funded at scale. Programs that aim to deliver breakthroughs in human health over 5 – 10 years. Founded by the Wellcome Trust in 2020 as a US nonprofit with initial funding of $300 million, Leap programs target complex human health challenges with the goal of achieving breakthrough scientific and technological solutions. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone.

With an additional $335 million in funding from the Wellcome Trust, the organization now has over half a billion dollars at work.

Share this work

Share on facebook
Share on twitter
Share on linkedin
Wellcome Leap Appoints
Ho Ching to Board of Directors
Wellcome Leap Appoints
Ho Ching to Board of Directors

March 18, 2021

Share this work

Share on facebook
Share on twitter
Share on linkedin

Los Angeles – March 18, 2021: Wellcome Leap (Leap), a U.S.-based non-profit organization founded by the Wellcome Trust to accelerate innovations that benefit global health, today announced the election of Ho Ching to its Board of Directors.

“We are pleased to welcome Ho Ching to Leap’s Board of Directors,” said Jay Flatley, Chairman of the Board. “Wellcome Leap is a global organization and Ms. Ho brings international business perspective and leadership to our efforts to create breakthroughs in human health.”

Ho Ching is Executive Director and CEO of Temasek Holdings, a global investment company headquartered in Singapore. Ms. Ho, who first joined Temasek Holdings in 2002, was appointed as CEO in 2004. Prior to joining Temasek, she started her career as an engineer and previously served as President and CEO of the Singapore Technologies Group from 1997 to 2001. From 1997 to 2002, she was the founding Chairman of Singapore Technologies Engineering.

“I am inspired by Leap’s mission to deliver breakthroughs in human health. They are asking the right questions, about how we can catalyse and support innovation for human health in a very purposeful way. The Covid-19 experience demonstrates clearly that when we connect the dots on multi-disciplinary, multi-national resources, and focus minds and capabilities to address specific global challenges, we can make a huge difference.” said Ho Ching.

Ms. Ho is a Distinguished Engineering Alumnus of the National University of Singapore, and an Honorary Fellow of the Institution of Engineers, Singapore. She is a graduate of the University of Singapore and holds a master’s in Electrical Engineering from Stanford University.

About Wellcome Leap

Wellcome Leap builds and executes bold, unconventional programs, funded at scale. Programs that aim to deliver breakthroughs in human health over 5 – 10 years. Founded by the Wellcome Trust in 2020 as a US nonprofit with initial funding of $300 million, Leap programs target complex human health challenges with the goal of achieving breakthrough scientific and technological solutions. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone.

Share this work

Share on facebook
Share on twitter
Share on linkedin

Wellcome Leap Establishes Global Network Dedicated to Accelerated Breakthroughs in Human Health

Charter group of 21 world-class institutions representing a network of over 150,000 researchers across six continents sign agreement that sets new bar for fast-paced research and development.

Charter group of 21 world-class institutions representing a network of
over 150,000 researchers across six continents sign agreement that sets new bar for fast-paced research and development.

Jan 28, 2021

Share this work

Share on facebook
Share on twitter
Share on linkedin

Los Angeles – Jan. 28, 2021: Wellcome Leap (Leap), a U.S.-based non-profit organization founded by the Wellcome Trust to accelerate innovations that benefit global health, today announced the first 21 participants in the Leap Health Breakthrough Network, a global group of leading academic and research institutions committed to solving the world’s most serious health challenges such as cancer and infectious diseases at record speed. 

The COVID-19 pandemic has underscored the importance of tackling urgent, large-scale health challenges quickly and across disciplines, organizations, and borders. It’s imperative that good ideas are identified and funded quickly, and that researchers across many institutions can build solutions together. 

Currently it can take as long as a year to finalize a research funding agreement, and when collaboration is required, work frequently cannot begin until all parties are signed further prolonging the delay. What’s more, key components needed to catalyze innovation sometimes come from individual researchers or smaller institutions that are often left out of major research initiatives. Breakthroughs require momentum, and diverse capabilities, wherever they exist globally.

The Leap Health Breakthrough Network will help eliminate barriers to progress thanks to the first-of-its-kind Master Academic Research Funding Agreement (MARFA), which equitably addresses all terms and conditions, including IP, ownership, and publication. Once an organization signs the MARFA, any researcher or group will need to negotiate only the statement of work and cost before funds can be transmitted and work can begin. Often in days, shaving months or more off of development timelines. 

“Science and engineering should move at the pace of breakthroughs, not the pace of contracting,said Leap CEO Regina E. Dugan. “Wellcome Leap has removed traditional obstacles to build a network that can mobilize and synchronize to solve problems in human health faster than has ever been possible.”

Charter signatories for the network include: Agency for Science, Technology and Research; California Institute of Technology; Carnegie Mellon University; Francis Crick Institute; Harvard John A. Paulson School of Engineering and Applied Sciences; Massachusetts Institute of Technology; National University of Singapore; University of Auckland; University of California, Los Angeles; University of California San Diego; University of Cape Town; University of Dundee; University of Pittsburgh; University of São Paulo; University of Southern California; Uppsala University; Vanderbilt University; Virginia Tech; Wellcome Sanger Institute; Wyss Center for Bio and Neuroengineering; and Wyss Institute for Biologically Inspired Engineering at Harvard University.

“The world has just seen an unprecedented scientific advance the delivery of a COVID-19 vaccine in 10 months,” said Richard Hatchett, CEO of the Coalition for Epidemic Preparedness Innovations. “Wellcome Leap has catalyzed a first-ever global network that will help deliver, well beyond this pandemic, new breakthroughs along what would previously have been considered impossible timelines.”

Participants in the Leap Health Breakthrough Network as well as commercial partners will play an ongoing part in Leap’s work to build and execute bold, unconventional programs, funded at scale. This includes efforts such as the $50 million Human Organs, Physiology, and Engineering (HOPE) program, announced in late 2020. 

Ken Gabriel, COO of Leap, said: “The opportunities for health breakthroughs are rich at the intersection of life sciences and engineering. This network will efficiently bring together collaborators from across disciplines to drive and deliver advances in global health.”

Institutions interested in joining the Leap Health Breakthrough Network should send an email to: HBNet@wellcomeleap.org.

About Wellcome Leap

Wellcome Leap builds and executes bold, unconventional programs, funded at scale. Programs that aim to deliver breakthroughs in human health over 5 – 10 years. Founded by the Wellcome Trust in 2020 as a US nonprofit with initial funding of $300 million, Leap programs target complex human health challenges with the goal of achieving breakthrough scientific and technological solutions. Operating at the intersection of life sciences and engineering, Leap programs require best-in-class, multi-disciplinary, global teams assembled from universities, companies, and nonprofits working together to solve problems that they cannot solve alone.

 

Quotes from Signatories

“There is a pressing need for scientists, engineers and innovators worldwide to work together as the world faces some of its biggest health challenges today. Wellcome Leap’s initiative to build and fund programmes targeting breakthroughs in human health is a much-needed opportunity for the international research community to collectively engage and advance scientific discovery, and catalyse health innovations. A*STAR is glad to be part of this global initiative alongside the National University of Singapore, and looks forward to contributing Singapore’s scientific capabilities towards accelerating progress for human health.”
Andy Hor, Deputy Chief Executive (Research) – Agency for Science, Technology and Research
“At Caltech, we welcome the opportunity to work with like-minded institutions that recognize the benefit of investing in high-risk, high-reward research, aiming to define new arenas of scientific discovery and technological impact.”

Thomas F. Rosenbaum, President – Caltech

“Carnegie Mellon is excited to be a charter member of the Wellcome Leap program, bringing research expertise from across the university to unleash breakthrough knowledge and solutions for global healthcare. This cross-disciplinary, collaborative approach to research is the defining element of CMU’s ability to innovate and do work that matters.”

Michael McQuade, Vice President for Research – Carnegie Mellon University 

“The Crick is excited by the opportunity to engage in such a novel and ambitious funding initiative. The multidisciplinary, global teams that Leap will enable have the potential to drive transformational benefits for human health. We look forward to seeing the impact.”

Sam Barrell, Chief Operating Officer – Francis Crick Institute

“MIT is committed to solving difficult problems in healthcare and doing so with the spirit of collaboration–we affirm the value of a global, multi-disciplinary approach to accelerate breakthroughs in this space.”

Martin Schmidt, Provost – Massachusetts Institute of Technology

“While the aim of biomedical research has not changed, the ways and means by which such research is conducted now draws in multiple partners and resources.  We applaud Wellcome Leap’s radical and innovative approach to funding use-inspired research, and look forward to partnering Leap along with the Agency for Science, Technology and Research in pursuit of transformational solutions to the health challenges of our time.”

Yap Seng CHONG, Dean of Yong Loo Lin School of Medicine – National University of Singapore

“The University of Auckland is delighted to be one of the charter signatories to this programme. Response to challenges such as Covid provide a critical example of the value of speed of response and harnessing global reach in ideas and capability that MARFA will enable.”

James Metson, Deputy Vice-Chancellor (Research) – University of Auckland

“We are honored for UCLA to become a part of Wellcome Leap’s global network, collaborating with other leading research institutions to advance human health through DARPA-like initiatives.”

Gene Block, Chancellor – University of California, Los Angeles

“UC San Diego has a shared interest in accelerating human health breakthroughs by engineering new technologies and applying them in research. Partnering with Leap allows our renowned researchers opportunities to collaborate with global, multi-disciplinary teams to advance the frontiers of knowledge and disseminate transformational discoveries.”

Pradeep K. Khosla, Chancellor – University of California San Diego

“The University of Cape Town looks forward to working with our fellow MARFA signatories to unleash truly transformative solutions to global challenges.”

Sue Harrison, Deputy Vice-Chancellor: Research and Internationalisation – University of Cape Town

“Dundee is proud to be a charter signatory of LEAP and to realising the collaborative advantage of this incredible network to accelerating health breakthroughs and transform lives.”

Iain Gillespie, Principal and Vice-Chancellor – University of Dundee

“The University of Pittsburgh is proud to play our part in this extraordinary opportunity. With our deep bench of health sciences innovators and bioengineering pioneers, Pitt can and will help fuel this ambitious global push to realize breakthroughs for society’s gain.” 

Patrick Gallagher, Chancellor – University of Pittsburgh

“Proud to join Wellcome Leap and alongside with important research institutions contribute to breakthroughs in science.”

Sylvio Canuto, Research Provost – University of São Paulo 

“USC is excited to play a role in this worldwide effort to bring teams from a wide range of disciplines together to accelerate advancements in human health. We believe partnerships between the public and private sectors will be key drivers to delivering breakthroughs on a global scale.

Carol L. Folt, President – University of Southern California

“Global health challenges must be addressed from many angles and perspectives. We are proud to take part in this urgent collaborative effort.”

Anders Hagfeldt, Vice-Chancellor – Uppsala University

“Today our society faces some of the greatest challenges ever known. But it is often these difficult moments that bring out the best in humanity. Vanderbilt’s research and scholarly mission has always been guided by a pursuit of excellence. We are pleased to join Wellcome Leap in a similar spirit of achieving breakthrough innovation through sustained commitment, intellectual rigor and a spirit of global collaboration across multiple disciplines and institutions.”

Daniel Diermeier, Chancellor – Vanderbilt University

“Virginia Tech and Wellcome Leap are aligned in taking on the most daunting challenges in human health and we are excited to be among the first universities with a research agreement that will facilitate our partnership in this ambitious effort.”

Tim Sands, President – Virginia Tech

“This is a fantastic and innovative initiative that offers huge potential. Global multi-disciplinary collaborations that accelerate science are at the heart of many of the Sanger Institute’s research efforts. We embrace such opportunities to stretch our imagination and explore new scientific possibilities at scale so that new discoveries can be made to support human health. This agreement and Leap are clearly a great way of strengthening and supporting this approach further.”

Martin Dougherty, Chief Operating Officer – Wellcome Sanger Institute

“The Wyss Center in Geneva is excited to be a member of the Leap community accelerating visionary science and technology.”

Mary Tolikas, CEO – Wyss Center for Bio and Neuroengineering

Institutions interested in joining the Leap Health Breakthrough Network should send an email to: HBNet@wellcomeleap.org.

Share this work

Share on facebook
Share on twitter
Share on linkedin