An international program with CEPI

Building a global network to catalyze next-generation treatments for disease.

Over the past three years, the RNA Readiness + Response (R3) program has united leading academics, technologists, and researchers to pioneer the continuous production of high-quality RNA – advancing treatments for conditions ranging from cancer to Zika. Based on the significant advances in the program, Wellcome Leap, CEPI, and their partners are now ready to scale this breakthrough globally. With a worldwide network of biofoundries, we aim to accelerate the production of next-generation medicines and simultaneously ensure an economically sustainable, on-demand capacity to respond rapidly to future pandemics.

Call for proposals.

New advanced brokerage for rapid discovery and production of RNA biologics.

Brokerage platform will service the first-ever, global marketplace to enable product developers and researchers access to state-of-the-art design and simulation tools and cost-effective, continuous-flow, scale-independent production of RNA products.

We are soliciting proposals for two phases of the brokerage rollout:

Phase 1 (2025 – 1H 2026): In this minimal viable product (MVP) phase, the brokerage will receive initial orders (targeting around 200-300 runs in the first 12 months) from selected commercial and academic customers to alpha / beta test end-to-end product and service delivery.

Phase 2 (2H 2026 – 2028): In its operational steady state, the brokerage service will manage the receipt and allocation of both Research Use Only (RUO) and Good Manufacturing Practice (GMP) orders under full commercial conditions. Delivery of this functionality will require additional service layers beyond the core brokerage platform, as outlined below.

Process and timeline
Call for Proposals announcement.

14 DAYS FOR PREPARATION AND SUBMISSION OF PROPOSAL

/ Day 1
Call for Proposals: 8 April 2025
/ Day 22
Deadline for Submission: 22 April 2025

Submissions will receive an email acknowledgement or request for a meeting with the R3 Global Team.

/ Day 29
Proposal Decision Sent: 29 April 2025
Mechanics of applying

Who is eligible?

Performers from small, medium, and large companies (including venture-backed); universities and research institutions; and government or non-profit research organizations are invited to propose.

We are seeking proposals from institutions and organizations with commercial experience in developing two sided markets or ecommerce platforms, including security, for Phase 1. Phase 2 will include elements of supply chain to negotiate agreements for reagents, LMP’s and field service.

Wellcome Leap agrees not to use any confidential information disclosed to it in a submitted proposal for any purpose other than the review of a proposal. Wellcome Leap will not use the information contained in a proposal for Leap’s direct or indirect personal or financial benefit and will not make such information available for the direct or indirect personal or financial benefit of any other organization or individual.

Wellcome Leap shall not disclose or permit disclosure of any confidential information with anyone who has not been officially designated by Leap to participate in a review and completed a confidentiality agreement. Wellcome Leap agrees that it shall take all reasonable measures to protect the secrecy of and avoid disclosure or use of confidential information in order to prevent it from falling into the public domain or the possession of unauthorized persons. Such measures shall include, but not be limited to, the same degree of care that Wellcome Leap utilizes to protect its own confidential information, which shall be no less than reasonable care. Wellcome Leap further agrees to promptly notify in writing of any actual or suspected misuse, misappropriation, or unauthorized disclosure of submitted confidential information which may come to Leap’s attention.

Notwithstanding the above, Wellcome Leap shall have no liability with regard to any information which Leap can prove:

(i) was in the public domain at the time it was disclosed or has entered the public domain through no fault of Leap;

(ii) was known to Leap, without restriction, at the time of disclosure, as demonstrated by files in existence at the time of disclosure;

(iii) is disclosed with the prior written approval of the submitter;

(iv) becomes known to Leap, without restriction, from a source other than Leap without breach of this statement; or

(v) is disclosed pursuant to the order or requirement of a court, administrative agency, or other governmental body; provided, however, that Leap shall provide prompt notice of such court order or requirement to submitter to enable submitter to seek a protective order or otherwise prevent or restrict such disclosure.

Furthermore, please recognize that Wellcome Leap may already by funding, or considering funding, the same or similar technology as covered by a submitted proposal—or have previously received from third parties—information or proposals similar to that which was submitted, that was not subject to confidentiality.

Wellcome Leap’s adherence to the above use of confidential information shall continue for a period of three (3) years from the receipt date of a submitted proposal.

Proposal application steps.

  1. Download Call for Proposals Guidelines.
  2. Click here to complete the application and upload your full proposal by 22 April 2025, 11:59pm ET.

Frequently asked questions.

If you have questions, please review our FAQ here. – updated 5 April 2025

Send inquiries to R3Global@wellcomeleap.org
Parker Moss

R3 Global is led by Parker Moss.

Parker Moss brings leadership in cancer and rare disease genomics, AI-driven drug discovery, and commercial partnerships across academia and biopharma. Previously he was an executive team member at the Cancer drug discovery biotech Exscientia, and also at Genomics England where he ran research and commercial partnerships. Parker was Entrepreneur in Residence at Fidelity-backed VC funds F-Prime and Eight Roads. Parker is currently a Non-Executive Director at Cancer Research Horizons (CRUK) and a member of the Cancer SAB at LifeArc.

R3 Global is a transition program catalyzed by the advances achieved in the R3 program led by Program Director, Duccio Medini, from 2021 to 2024.

Learn More about the original R3 program here.

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