CHANGES IN TISSUE STATE
CHANGES IN TISSUE STATE







Leap builds bold, unconventional programs and funds them at scale.
Programs that aim to deliver breakthroughs in human health over 5 – 10 years and demonstrate seemingly impossible results on seemingly impossible timelines.
Our programs require best-in-class, multi-disciplinary, global teams from universities, companies, and non-profit labs working together to solve problems they cannot solve alone.
Leap is a global ARPA for health.
Just as Sputnik ignited the Space Age, so too could the coronavirus inspire
The Health Age.
The right time.
The right time.
On October 4, 1957, a beach-ball-sized satellite we know as Sputnik was launched into orbit. It inspired a new curiosity about a new frontier.
Sputnik was an inflection point. It led to one of the greatest periods of advancement in science and engineering in history.
The global pandemic has laid bare how much there is to do in health, from policy to equity to financing. But it has also revealed the difference a scientific breakthrough makes. We need more breakthroughs and we need them faster.
Just as Sputnik ignited the Space Age, so, too, might the coronavirus inspire a Health Age. Not just to defeat future pandemics, but to make urgent progress on cancer, mental health, and more.


The right time.
The right time.
On October 4, 1957, a beach-ball-sized satellite we know as Sputnik was launched into orbit. It inspired a new curiosity about a new frontier.
Sputnik was an inflection point. It led to one of the greatest periods of advancement in science and engineering in history.
The global pandemic has laid bare how much there is to do in health, from policy to equity to financing. But it has also revealed the difference a scientific breakthrough makes. We need more breakthroughs and we need them faster.
Just as Sputnik ignited the Space Age, so, too, might the coronavirus inspire a Health Age. Not just to defeat future pandemics, but to make urgent progress on cancer, mental health, and more.


The right model.
The right model.
Leap is built on a unique model of innovation practiced at DARPA.
For more than six decades, this model has been an uninterrupted engine of breakthrough innovation. It is not a discovery science model, but neither is it a pure application model. It sits firmly at the intersection of the two.
Work in what we call Pasteur’s Quadrant demands that we set ambitious goals that are measurable and testable. So that we’ll know if we succeeded or failed. It requires that we intersect life sciences and engineering, so that we can demonstrate advances at convincing scale — because that’s how an idea once thought impossible, is seen as possible.
The right leadership.
The right leadership.
Led by Leap CEO, Regina E. Dugan, who served as the 19th Director of DARPA, where she oversaw an annual $3B portfolio of projects ranging from hypersonics to RNA-based vaccines. An experienced Silicon Valley executive, she also built and led advanced project organizations at Google and Facebook.
Chaired by one of the most effective business leaders in the life sciences industry, Jay Flatley. As CEO of Illumina, Jay helped to transform gene sequencing from a scientific pursuit to a commercially accessible service and moved the cost of sequencing an entire human genome from $1 million to $1,000.
Founded by visionaries Jeremy Farrar, Mike Ferguson, and the Wellcome Trust Leadership with a $300M seed investment, Leap intends to assemble international partners such that together we create the critical mass of funding required.