Frequently Asked Questions

About the Human Organs, Physiology, and Engineering (HOPE) program

How many awards will be funded?

There are no pre-set number of awards.

How much is each individual award?

Award amounts will be dependent on specific proposals and work selected for funding.

Is the Program open to applicants from outside the United States and UK?

Yes, it is open to applicants around the world.

What is the working model or program structure of HOPE?

HOPE requires best-in-class biologists, engineers, clinicians, computational scientists assembled from universities, companies, and nonprofits. Success will come from working together across these sectors.

To that end, Leap programs are actively led and orchestrated by a Program Director who adjusts, iterates, and directs teams working together so as to solve problems they cannot solve alone.

Is Leap accepting proposals on organ transplant targeting other organs than the kidney?

Yes. The proposed work in one or more Thrust Area(s) should clearly be related to the success of the organ transplant goal.

Are animal studies excluded?

No. Animal studies are not precluded as tools to support the hypothesis towards the main goal of recapitulating human physiology in human-based models.

Who can I contact if I have a question about the Human Organs, Physiology, and Engineering program?

Send an email with your question to

Application Process

Is there a specific format for the application?

Please see the program announcement for format guidance.

Is the online application portal the only way to provide a submission?


Is it possible to have multiple applicants on a submission?

Yes. Multiple collaborators can be on a single submission, but only the Principal Investigator (PI) will be able to submit the application on the portal.

Is it necessary to form a consortium when applying?

No. We encourage individuals or small teams to apply in the thrust area(s) best aligned with their expertise and capabilities. It is not necessary to form a large consortium or team a priori to address all thrusts or an entire goal in a single abstract or proposal. Indeed, we intend to facilitate synergies dynamically among HOPE performers as we make progress together toward the program’s goals.

What are the eligible costs?

Please include any costs appropriate to the execution of the proposed research and follow the guidelines of the program announcement.

Can you have multiple submissions? 


Am I able to edit my submission once submitted?


When will I receive feedback on my submission?

Please see the program announcement for the program timeline.

May I still submit a full proposal if I receive a recommendation to not submit on my abstract feedback? 


Review Process

Will my idea be treated as confidential during the review process?

Please see the program announcement for a discussion of confidentiality of submissions.

What is the review process?

Please see the program announcement for information on the review process in each round.